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Eating less and moving more are the basics of weight loss that lasts. For some people, prescription weight loss drugs may help. You'll still need to focus on diet and exercise while taking these drugs, and they're not for everyone. Doctors usually prescribe them only if your BMI is 30 or higher, or if it's at least 27 and you have a condition that may be related to your weight, like type 2 diabetes or high blood pressure lék na hubnutí.